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Re: Alzheimer's Disease
[Re: Suzanne]
#180171
04/11/16 10:53 PM
04/11/16 10:53 PM
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OP
SDA
Active Member 2016
Dedicated Member
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Joined: Aug 2009
Posts: 1,275
Calif. USA
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Curcumin Eradicates Brain Protein Fragments To Fight Alzheimer's Disease
by Julie Wilson staff writer
(NaturalNews) A debilitating disease that causes difficulty remembering recent conversations, names or events, Alzheimer's, is the sixth leading cause of death in the United States, affecting more than 5 million Americans.
Women are particularly at risk for the disease, making up two-thirds of Alzheimer's cases. Women in their 60s are about twice as likely to develop Alzheimer's disease during the rest of their lives as they are to develop breast cancer, according to data provided by the Alzheimer's Association.
Also at issue is the health of the primary caregivers of those with Alzheimer's and dementia. The emotional stress of caring for someone with the disease has been rated as "high" or "very high," with one-third of caregivers reporting symptoms of depression.
In just a decade, deaths related to Alzheimer's have increased by 68 percent! "Alzheimer's disease is the only cause of death among the top 10 in America that cannot be prevented, cured or even slowed," the Alzheimer's Association reported.
In the U.S., someone develops Alzheimer's disease every 67 seconds
However, recent scientific breakthroughs involving turmeric, a popular, ancient Indian spice, offers new hope for those affected by Alzheimer's disease. Curcumin, one of turmeric's most beneficial compounds, has been proven to fight pain and inflammation, as well as help stimulate stem cell growth, a remarkable breakthrough for Alzheimer's and dementia research.
Researchers now believe that turmeric could be key in helping repair brain damage in humans.
"Curcumin has demonstrated ability to enter the brain, bind and destroy the beta-amyloid plaques present in Alzheimer's with reduced toxicity," said Wellington Pham, Ph.D., assistant professor of Radiology and Radiological Sciences and Biomedical Engineering at Vanderbilt University and senior author of the study, published recently in the Journal of Alzheimer's Disease.
"Accumulation and aggregation of protein fragments, known as beta-amyloid, drives the irreversible loss of neurons in Alzheimer's disease," reports News.Vanderbilt.edu.
"Developing small molecules to reduce this accumulation or promote its demolition is crucial, but the ability of these small molecules to cross the blood-brain barrier has been a restricting factor for drug delivery into the brain."
Scientists develop new way to deliver turmeric compounds across blood brain barrier
In order to overcome this obstacle, Pham and his colleagues at Shiga University of Medical Science in Otsu, Japan, came up with a new way to deliver curcumin-like molecules to the brain more effectively.
"One of the difficulties in the treatment of Alzheimer's disease is how to deliver drugs across the blood brain barrier," Pham explained.
"Our body has designed this barrier to protect the brain from any toxic molecules that can cross into the brain and harm neurons," he said. "But it is also a natural barrier for molecules designed for disease-modifying therapy."
Delivering drugs to the cortex and hippocampus is much more efficient using a curcumin aerosol compared to injecting it intravenously, scientists say
To circumvent the problems with giving the drug intravenously, Japanese scientists created an atomizer to generate a curcumin aerosol, using a molecule similar to curcumin called FMeC1.
"The advantage of the FMeC1 is that it is a perfluoro compound, which can be tracked by the biodistribution in the brain noninvasively using magnetic resonance imaging," Pham said. "Curcumin is a very simple chemical structure, so it is not expensive to generate the analog.
"In this way the drug can be breathed in and delivered to the brain," said Pham, adding that nebulizers are already available on the market and are relatively inexpensive.
"In this paper we also showed that delivery to the cortex and hippocampal areas is more efficient using aerosolized curcumin than intravenous injection in a transgenic mouse model of Alzheimer's disease," concluded Pham and his team.
Sources:
http://news.vanderbilt.edu
http://www.alz.org
http://www.naturalnews.com
http://www.naturalnews.com
http://www.ninds.nih.gov
http://science.naturalnews
-Suzanne-
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Re: Alzheimer's Disease
[Re: Suzanne]
#180394
04/27/16 10:18 PM
04/27/16 10:18 PM
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OP
SDA
Active Member 2016
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Joined: Aug 2009
Posts: 1,275
Calif. USA
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Blueberries Shown To Boost Brain Activity In Advanced Alzheimer's Patients
by S. Johnson
(NaturalNews) Chock full of antioxidants, blueberries are touted as a superfood that can ward off heart disease and cancer. Adding to the list of potential health benefits, a recent study found that blueberries can help provide protection against Alzheimer's disease.
The researchers presented their findings at the National Meeting & Exposition of the American Chemical Society (ACS). The ACS is the world's largest scientific society. There will be approximately 12,500 presentations on a vast range of science-related topics at this year's meeting.
"Our new findings corroborate those of previous animal studies and preliminary human studies, adding further support to the notion that blueberries can have a real benefit in improving memory and cognitive function in some older adults," said the leader of the research project, Robert Krikorian, Ph.D.
Krikorian attributed the medicinal benefits of blueberries to a flavonoid known as anthocyanins, which has been shown to improve cognition in animals.
A growing problem
An estimated 5.2 million people are afflicted with Alzheimer's disease. That number is expected to grow along with the rest of the US population. The Alzheimer's Association warns that the number of Americans with Alzheimer's disease is expected to swell to 7 million people by 2025, and possibly triple by 2050.
In an attempt to unlock ways to slow the progression of the disease, Krikorian and his team conducted two new studies that investigated the medicinal impact that blueberries had on cognitive performance. The first study consisted of 47 adults aged 68 years or older who were beginning to show symptoms of Alzheimer's disease.
The researchers conducted a test and brain scan on each patient. They then gave some of the participants the equivalent of a single cup of berries in a freeze-dried powder form, and the other participants a placebo. The study lasted 16 weeks.
"There was improvement in cognitive performance and brain function in those who had the blueberry powder compared with those who took the placebo," Krikorian noted in a press release. "The blueberry group demonstrated improved memory and improved access to words and concepts," he added. The researchers also conducted functional magnetic resonance imaging (fMRI), which revealed a spike in brain activity among participants who were fed the blueberry powder.
The second study consisted of 94 people aged 62 to 80 who were divided into four groups. No objective, third-person measures showed that the patients were suffering from cognitive issues; however, the participants reported that their memories were on the decline. The researchers believed the second group had better cognitive health than the first group, but this was not verified using third-person measures. The groups were given blueberry powder, fish oil, fish oil with powder or a placebo.
"The results were not as robust as with the first study," Krikorian noted. "Cognition was somewhat better for those with powder or fish oil separately, but there was little improvement with memory." In addition, fMRI results did not show a significant spike in brain activity among the blueberry power group. Krikorian speculated the blueberries were not as effective because participants' had less severe cognitive problems entering the study.
Eat more blueberries
Krikorian said that the results of the two studies suggest that blueberries may be more effective for people with advanced cognitive issues but may not show measurable results for patients with minor memory problems.
In the future, the researchers plan to conduct a blueberry study on younger people aged 50 to 65. The group will consist of people who have an increased risk of developing Alzheimer's, including those who are obese, have high blood pressure or high cholesterol. It's hoped that the work will shed light on whether blueberries can help stymie Alzheimer's symptoms before they begin.
To learn more about how you can transform your health for the better through healthy eating habits, check out this year's fifth annual Food Revolution Summit, featuring 24 of the top healthy food experts on the plant. Click here to reserve your spot for this FREE online event today!
Sources include:
Telegraph.co.uk
FreshPlaza.com
Business-Standard.com
EurekAlert.org
Science.NaturalNews.com
NaturalNews.com
-Suzanne-
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