It is indeed negative for the bacteria and virus themselves, because if they cause the death of the being they invade, they are virtually causing their own death.

First, Ellen White is speaking of amalgamation of men and of animals, not of men with animals.

I'll transcribe from the White Estate, since there is no link:

Amalgamation of man and beast
Some have charged that Ellen White wrote in 1864 (and republished in 1870) that humans once cohabited with animals and that their offspring produced certain races that exist today. The statement reads: "But if there was one sin above another which called for the destruction of the race by the flood, it was the base crime of amalgamation of man and beast which defaced the image of God, and caused confusion everywhere. God purposed to destroy by a flood that powerful, long-lived race that had corrupted their ways before Him." [1]

No dictionary has ever used "amalgamation" to describe the cohabitation of man with beast. The primary use of the word describes the fusion of metals, the union of different elements such as in making tooth cements. Nineteenth-century usage included the mixing of diverse races.

Granted, her statement could appear ambiguous: Does she mean "amalgamation of man with beast" or "amalgamation of man and of beast"? Often, repetition of the preposition is omitted in similar construction. [2]

On other occasions, when Mrs. White used the word "amalgamation," she used it metaphorically, comparing faithful believers and worldlings. [3] She also used it to describe the origin of poisonous plants and other irregularities in the biological world: "Christ never planted the seeds of death in the system. Satan planted these seeds when he tempted Adam to eat of the tree of knowledge which meant disobedience to God. Not one noxious plant was placed in the Lord's great garden, but after Adam and Eve sinned, poisonous herbs sprang up. . . . All tares are sown by the evil one. Every noxious herb is of his sowing, and by his ingenious methods of amalgamation he has corrupted the earth with tares." [4]

Recognizing that Satan has been an active agent in the corrupting of God's plan for man, beast, plants, etc., we can better understand what Ellen White may have meant when she described the results of amalgamation. That which "defaced the image of God" in man and that which "confused the species [of animals]" has been the handiwork of Satan with the cooperation of humans. Such "amalgamation of man and [of] beast, as may be seen in the almost endless varieties of species of animals, and in certain races of men," becomes understandable.

Mrs. White never hinted of subhuman beings or any kind of hybrid animal-human relationship. She did speak of "species of animals" and "races of men" but not any kind of amalgam of animals with human beings.

We recognize, however, that serious students of Ellen White's writings differ on what she meant by "amalgamation." "The burden of proof rests on those who affirm that Mrs. White gave a new and alien meaning to the term." [5]

[1] Spiritual Gifts, vol. 3, p. 64. "Every species of animal which God had created were preserved in the ark. The confused species which God did not create, which were the result of amalgamation, were destroyed by the flood. Since the flood there has been amalgamation of man and beast, as may be seen in the almost endless varieties of species of animals, and in certain races of men" (page 75).

[2] "We might speak of the scattering of man and beast over the earth, but we do not therefore mean that previously man and beast were fused in one mass at one geographical spot. We simply mean the scattering of man over the earth and the scattering of beasts over the earth, though the original location of the two groups might have been on opposite sides of the earth. In other words, the scattering of man and of beast" (Francis D. Nichol, Ellen G. White and Her Critics, p. 308).

[3] "Those who profess to be followers of Christ, should be living agencies, cooperating with heavenly intelligences; but by union with the world, the character of God's people becomes tarnished, and through amalgamation with the corrupt, the fine gold becomes dim" (Review and Herald, Aug. 23, 1892; see also The Spirit of Prophecy, vol. 2, p. 144 and The Upward Look, p. 318).

[4] Selected Messages, book 2, p. 288.

[5] Nichol, Ellen G. White and Her Critics, p. 308.

Who said any animal would have been created from scratch? Satan and humans can only make changes through genetic manipulation and engeneering. They can't create from scratch.

By the way, when Ellen White speaks of the evidence of amalgation in certain races of men, she may be referring to certain physical traits besides the spiritual aspect - perhaps a combination of both. Of course through amalgamation certain physical traits are reinforced or modified. This article and many others use the term "amalgamation" and comment about the effect of this regarding physical traits.

Thomas, earlier on this thread I posted Bible quotes. Like you, I am also quoting other sources. I am simply saying God guided the species of animals that He created onto the ark, that He did not guide the ones He didn't "create", and that the species He didn't "create" perished in the flood resulting in their extinction. I guess it doesn't matter if we call the original species God created "dinosaurs", so long as we agree He created them.

Do you disagree with these observations?

Not if the bacteria would be killed by the host immune defence without the mutation. Then the bacteria wins in the long run if even one other host is infected before the current host dies.

Like the groups known as mullato and latino in america?

Does this suggest that Ellen meant by amalgamation the same as Augustine meant by original sin? In such case this is only confusing to anyone today.

But with the admision that humans and others can only made changes to such animals which God has created, and since it is an undisputed fact that dinosaurs did exist, therefore God must have created them, even though some of the subspecies might have been tweaked by other entities.

We have two quotes – one which says that genetically manipulated animals perished in the flood and one which says that a very large class of animals perished in the flood.